MOTS-C (10mg)

MOTS-c 10mg, a mitochondrial-derived peptide for metabolic and exercise research. (99%) Purity verified here on Australian soil at The University of Melbourne.

MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16-amino acid peptide encoded within the mitochondrial genome, first described in 2015 by the Cohen laboratory at the University of Southern California. It represents one of the few known peptides encoded by mitochondrial DNA rather than nuclear DNA.

The peptide sequence (MRWQEMGYIFYPRKLR) is translated from a short open reading frame within the 12S rRNA gene of mitochondrial DNA. This discovery opened a new field of research into mitochondrial-derived peptides (MDPs) and their roles as signalling molecules in metabolic regulation.

Research has examined MOTS-c’s effects on AMPK (AMP-activated protein kinase) activation, a master regulator of cellular energy metabolism. Studies have investigated its influence on glucose uptake, fatty acid oxidation, and metabolic homeostasis in various experimental models.

Additional research has explored MOTS-c’s effects in exercise physiology contexts, including its potential role as an exercise-mimetic and its changes in response to physical activity. Studies have also investigated age-related changes in MOTS-c levels and their potential implications for metabolic health.

Note: MOTS-c may be less stable than many peptides — minimise time outside refrigeration during handling to maintain peptide integrity.

Gen Ex Peptides supplies MOTS-c tested at an Australian university laboratory not generic overseas certificates. Each batch is verified for purity (99%) using HPLC and mass spectrometry.